@font-face{font-family:Archivo;src:url(/static/frontend/assets/archivo-latin-wdth-normal-DY7AcnAa.woff2)format("woff2-variations");font-weight:100 900;font-stretch:62% 125%;font-style:normal;font-display:swap}@font-face{font-family:Archivo;src:url(/static/frontend/assets/archivo-latin-wdth-italic-BuvkOFDm.woff2)format("woff2-variations");font-weight:100 900;font-stretch:62% 125%;font-style:italic;font-display:swap}@font-face{font-family:Archivo Fallback Display;src:local(Arial Bold),local(Arial-BoldMT),local(Arimo Bold),local(Arimo-Bold),local(Liberation Sans Bold),local(LiberationSans-Bold);font-weight:100 900;font-stretch:50% 200%;font-style:normal;size-adjust:70.68%;ascent-override:124.23%;descent-override:29.71%;line-gap-override:0%}@font-face{font-family:Archivo Fallback Wordmark;src:local(Arial Bold),local(Arial-BoldMT),local(Arimo Bold),local(Arimo-Bold),local(Liberation Sans Bold),local(LiberationSans-Bold);font-weight:100 900;font-stretch:50% 200%;font-style:normal;size-adjust:76.05%;ascent-override:115.46%;descent-override:27.61%;line-gap-override:0%}@font-face{font-family:Archivo Fallback Figure;src:local(Arial Bold),local(Arial-BoldMT),local(Arimo Bold),local(Arimo-Bold),local(Liberation Sans Bold),local(LiberationSans-Bold);font-weight:100 900;font-stretch:50% 200%;font-style:normal;size-adjust:78.61%;ascent-override:111.69%;descent-override:26.71%;line-gap-override:0%}@font-face{font-family:Archivo Fallback Heading;src:local(Arial Bold),local(Arial-BoldMT),local(Arimo Bold),local(Arimo-Bold),local(Liberation Sans Bold),local(LiberationSans-Bold);font-weight:100 900;font-stretch:50% 200%;font-style:normal;size-adjust:85.26%;ascent-override:102.97%;descent-override:24.63%;line-gap-override:0%}@font-face{font-family:Archivo Fallback Label;src:local(Arial Bold),local(Arial-BoldMT),local(Arimo Bold),local(Arimo-Bold),local(Liberation Sans Bold),local(LiberationSans-Bold);font-weight:100 900;font-stretch:50% 200%;font-style:normal;size-adjust:89.03%;ascent-override:98.62%;descent-override:23.59%;line-gap-override:0%}@font-face{font-family:Archivo Fallback Ui;src:local(Arial),local(ArialMT),local(Arimo),local(Arimo-Regular),local(Liberation Sans),local(LiberationSans);font-weight:100 900;font-stretch:50% 200%;font-style:normal;size-adjust:92.85%;ascent-override:94.56%;descent-override:22.62%;line-gap-override:0%}@font-face{font-family:Archivo Fallback Body;src:local(Arial),local(ArialMT),local(Arimo),local(Arimo-Regular),local(Liberation Sans),local(LiberationSans);font-weight:100 900;font-stretch:50% 200%;font-style:normal;size-adjust:98.12%;ascent-override:89.48%;descent-override:21.4%;line-gap-override:0%}:root,:root.tbv2,:root[data-theme=dark] :is(.topbar,.cloth,.footer,.skip,.pt-cloth,.keep-light){--cloth-ground:var(--accent-navy);--cloth:var(--cloth-ground);--cloth-deep:#101a2f;--cloth-hi:#1f2e4d;--cloth-line:#34445f;--thread:#f1f4f8;--thread-2:#c3cad5;--accent-navy:#15213a;--accent-velvet:#5f162b;--accent-green:#09281b;--paper:#f8fafc;--shirt:#fff;--paper-2:#edf1f5;--tape:#eaeef3;--ink:#1c2129;--text:#39404b;--muted:#586170;--rule:#e0e5eb;--chalk:#b9c1cc;--field:#8f99a7;--oxblood:#7b1e2b;--resistant:#7b1e2b;--rate-4:#7b1e2b;--rate-3:#9e3d4a;--rate-2:#c47c86;--rate-1:#e4bfc4;--pheno-s:#cfd6df;--g1:#7b1e2b;--g2:#b45f6b;--g3:#959eab;--g4:#586a87;--g5:#15213a;--p-sus:#d4e4d7;--p-hr:#a6cbae;--p-rr:#74aa83;--p-mdr:#46895c;--p-pre:#266640;--p-xdr:#0f3d23;--class-1:#2e3440;--class-2:#6a717c;--class-3:#a5abb3;--class-4:#d5d9de;--warn-1:#b4531b;--warn-2:#c98a17;--warn-3:#dfc04b;--warn-ink:#8a4210;--warn-bg:#f8efdc;--info-1:#2f5f8f;--info-2:#7fa3c7;--info-3:#c8d8ea;--info-green:#2d6b62;--info-green-2:#9cc8bf;--info-bg:#eaf1f8;--heat-rgb:21, 33, 58;--data-ground:#fff;--data-ink:#1c2129;--data-paper:#fff;--mark-cloth:#15213a;--mark-edge:#1c212973;--tick-fine:#8b94a1;--tick-minor:#59616e;--sil-cloth:#1f2d4b;--sil-paper:#dee3e9;--disabled-ink:#646d7b}:root[data-theme=dark],:root[data-theme=dark] :is(.hsearch-drop,.theme-pop){--lightningcss-light: ;--lightningcss-dark:initial;color-scheme:dark;--cloth:#a9bcdc;--cloth-deep:#c7d4ea;--mark-cloth:#a9bcdc;--paper:#0e131b;--shirt:#131a25;--paper-2:#1f2836;--tape:#232d3c;--ink:#e8ecf2;--text:#c3cad5;--muted:#939dac;--rule:#242d3a;--chalk:#3a4556;--field:#647083;--oxblood:#f08a98;--warn-1:#e48b55;--warn-2:#d2a03e;--warn-3:#dcc566;--warn-ink:#efb685;--warn-bg:#2a2117;--info-1:#94b8de;--info-2:#5f83a9;--info-3:#2e4562;--info-green:#7cc2b5;--info-green-2:#3d7066;--info-bg:#162133;--mark-edge:#e8ecf273;--tick-fine:#4c5767;--tick-minor:#7c8696;--sil-paper:#182030;--disabled-ink:#6e7889}:root[data-accent=velvet],:root[data-accent=velvet][data-theme=dark] :is(.topbar,.cloth,.footer,.skip,.pt-cloth,.keep-light){--cloth-ground:var(--accent-velvet);--cloth-deep:#521425;--cloth-hi:#771c37;--cloth-line:#8a3c4e;--sil-cloth:#741d36;--thread:#f9f2f3;--thread-2:#d7c4c7;--paper:#fdf9f9;--paper-2:#f6eeef;--tape:#f4ebec;--rule:#ede1e3;--chalk:#cfbabd;--sil-paper:#ebdfe1}:root[data-accent=velvet][data-theme=dark],:root[data-accent=velvet][data-theme=dark] :is(.hsearch-drop,.theme-pop){--cloth:#dcadb4;--cloth-deep:#eacace;--paper:#1c0e11;--shirt:#261317;--paper-2:#382024;--tape:#3e2429;--rule:#3c2529;--chalk:#583b40;--sil-paper:#31171c}:root[data-accent=green],:root[data-accent=green][data-theme=dark] :is(.topbar,.cloth,.footer,.skip,.pt-cloth,.keep-light){--cloth-ground:var(--accent-green);--cloth-deep:#062015;--cloth-hi:#103726;--cloth-line:#2c4b3c;--sil-cloth:#113626;--thread:#f0f5f2;--thread-2:#c0cdc6;--paper:#f8faf9;--paper-2:#edf2ef;--tape:#e9efec;--rule:#dfe7e2;--chalk:#b7c4bd;--sil-paper:#dde5e0}:root[data-accent=green][data-theme=dark],:root[data-accent=green][data-theme=dark] :is(.hsearch-drop,.theme-pop){--cloth:#a1d9c2;--cloth-deep:#c8edde;--paper:#0b1510;--shirt:#0f1d16;--paper-2:#1a2c23;--tape:#1e3128;--rule:#203128;--chalk:#354a3f;--sil-paper:#10251b}:root .cloth,:root[data-theme=dark] .cloth{--mark-edge:#f1f4f866}:root[data-theme=dark] :is(.topbar,.cloth,.footer,.skip,.pt-cloth,.keep-light){--lightningcss-light:initial;--lightningcss-dark: ;color-scheme:light}:root,:root.tbv2{--font:"Archivo", "Archivo Fallback Body", "Helvetica Neue", Arial, sans-serif;--font-display:"Archivo", "Archivo Fallback Display", "Helvetica Neue", Arial, sans-serif;--font-wordmark:"Archivo", "Archivo Fallback Wordmark", "Helvetica Neue", Arial, sans-serif;--font-figure:"Archivo", "Archivo Fallback Figure", "Helvetica Neue", Arial, sans-serif;--font-heading:"Archivo", "Archivo Fallback Heading", "Helvetica Neue", Arial, sans-serif;--font-label:"Archivo", "Archivo Fallback Label", "Helvetica Neue", Arial, sans-serif;--font-ui:"Archivo", "Archivo Fallback Ui", "Helvetica Neue", Arial, sans-serif;--fs-xs:12.5px;--fs-sm:14px;--fs-base:16px;--fs-md:18px;--fs-lg:24px;--fs-display-xl:96px;--fs-display-l:92px;--fs-display-s:68px;--w-display:64%;--w-wordmark:70%;--w-figure:76%;--w-heading:84%;--w-label:90%;--w-ui:92%;--s1:4px;--s2:8px;--s3:12px;--s4:16px;--s5:24px;--s6:32px;--s7:48px;--s8:64px;--wrap:1280px;--gut:40px;--bar-h:56px;--col-gap:64px;--field-gap:24px;--field-row-gap:12px;--icon-gap:6px;--gap-section:64px;--gap-region:48px;--gap-block:32px;--gap-content:16px;--gap-caption:12px;--gap-footer:96px;--hero-title-fs:var(--fs-display-l);--home-title-fs:var(--fs-display-xl);--hero-crumbs-pt:24px;--hero-crumbs-lh:24px;--hero-pt:24px;--hero-pb:48px;--hero-note-fs:22px;--hero-line-gap:16px;--hero-facts-w:520px;--ctl-h:36px;--ctl-h-hero:52px;--ctl-hero-frame:7px;--ctl-hero-inset:5px;--ctl-px:16px;--field-px:10px;--tab-h:50px;--tab-pt:14px;--tab-pb:12px;--tab-gap:6px;--select-caret:30px;--field-icon-px:32px;--badge-px:5px;--crumb-sep-mx:10px;--disclose-w:18px;--cell-py:10px;--cell-px:14px;--th-pt:12px;--th-pb:10px;--row-lh:19px;--th-lh:17px;--row-h:40px;--row2-h:59px;--facts-px:24px;--facts-py:12px;--facts-term-lh:20px;--facts-fig:28px;--facts-fig-lh:32px;--facts-row-fig:30px;--facts-row-fig-lh:33px;--facts-gap:8px;--sec-head-pb:16px;--sil:130px;--sil-room:calc(var(--sil) + 24px);--band-sticky-h:0px;--radius:0;--ease:ease-out;--t-fast:.15s;--t-move:.4s;--ease-move:cubic-bezier(.25, .25, .2, 1)}@media (width<=600px){:root,:root.tbv2{--gut:20px;--bar-h:52px;--gap-section:48px;--gap-region:32px;--gap-block:24px;--hero-title-fs:min(var(--fs-display-s), calc((100vw - 2 * var(--gut)) / 5.3));--home-title-fs:72px;--hero-pb:32px;--hero-note-fs:18px;--ctl-h-hero:46px;--ctl-hero-frame:5px;--facts-px:12px;--facts-fig:24px;--facts-fig-lh:28px;--facts-row-fig:26px;--facts-row-fig-lh:29px;--sil:100px}}*{box-sizing:border-box}html,:root.tbv2{-webkit-text-size-adjust:100%;scrollbar-color:var(--chalk) var(--paper-2);background:var(--cloth-ground);scroll-behavior:smooth;scrollbar-gutter:stable}body,:root.tbv2 body{font-family:var(--font);font-size:var(--fs-base);color:var(--text);text-align:left;caret-color:var(--cloth);-webkit-font-smoothing:antialiased;font-variant-numeric:lining-nums;background:0 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0);white-space:nowrap;width:1px;height:1px;position:absolute;overflow:hidden}.id{font-family:var(--font-ui);font-weight:620;font-stretch:var(--w-ui);font-variant-numeric:tabular-nums;letter-spacing:.01em;color:var(--ink)}a.id{color:var(--ink);text-underline-offset:3px;text-decoration-line:underline;text-decoration-thickness:1px;-webkit-text-decoration-color:var(--field);text-decoration-color:var(--field)}a.id:hover{color:var(--ink);text-decoration-color:currentColor}span.id{cursor:auto;text-decoration:none}.cloth a.id{color:var(--thread);-webkit-text-decoration-color:var(--thread-2);text-decoration-color:var(--thread-2)}.cloth a.id:hover{color:var(--shirt);-webkit-text-decoration-color:var(--shirt);text-decoration-color:var(--shirt)}.hgvs{font-variant-numeric:tabular-nums;letter-spacing:.005em;color:var(--ink);font-weight:520;font-stretch:94%}.drug{font-family:var(--font-label);font-weight:650;font-stretch:var(--w-label);letter-spacing:.04em;color:var(--ink)}.lname{font-family:var(--font-ui);font-weight:650;font-stretch:var(--w-ui);color:var(--ink)}.keep-light{color:var(--text)}.wrap{max-width:var(--wrap);padding:0 var(--gut);margin:0 auto}.skip{left:-999px;top:var(--s2);z-index:100;background:var(--thread);color:var(--cloth);padding:var(--s2) var(--s3);position:absolute}.skip:focus{left:8px}.tip{z-index:5;pointer-events:none;min-width:210px;padding:var(--s2) var(--s3);background:var(--shirt);border:1px solid var(--ink);font-size:var(--fs-sm);color:var(--text);line-height:1.45;display:none;position:absolute;top:0;left:0}.tip .t-head{color:var(--ink);font-weight:700;font-stretch:var(--w-label)}.tip .t-total{color:var(--muted);margin-bottom:var(--s1);font-variant-numeric:tabular-nums}.tip .t-row{align-items:center;gap:var(--s2);display:flex}.tip .t-row i{width:9px;height:9px;box-shadow:inset 0 0 0 1px var(--mark-edge);flex:none;display:inline-block}.tip .t-row b{padding-left:var(--s4);color:var(--ink);font-variant-numeric:tabular-nums;margin-left:auto;font-weight:650}.tip .t-top{margin-top:var(--s2);padding-top:var(--s2);border-top:1px solid var(--rule)}.keep-w{justify-items:start;display:inline-grid}.keep-w>span,.keep-w:after{grid-area:1/1}.keep-w[data-label]:after,.keep-w>.keep-w-ghost{font-weight:var(--keep-w-weight,700);visibility:hidden;pointer-events:none;-webkit-user-select:none;user-select:none;height:0}.keep-w[data-label]:after{content:attr(data-label) / ""}.keep-w>.keep-w-alt{font-weight:inherit}@media (width<=600px){h2{font-size:21px}}@media 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svg{width:100%;height:100%;display:block}.cloth .bigicon{color:var(--sil-cloth)}.bigicon.on-paper{color:var(--sil-paper)}.button .ico,.linkbtn .ico{color:currentColor}[aria-expanded=true]>.ico.turn{transform:rotate(180deg)}.ico.turn{transition:transform var(--t-fast) var(--ease)}.hsearch{width:100%;position:relative}.hsearch-box{align-items:center;display:flex;position:relative}.hsearch-lead{left:var(--field-px);color:var(--thread-2);pointer-events:none;position:absolute}.hsearch-input{width:100%;height:var(--ctl-h);padding:0 var(--s2) 0 var(--field-icon-px);font:inherit;font-family:var(--font-ui);font-size:var(--fs-sm);font-stretch:var(--w-ui);color:var(--shirt);background:var(--cloth-deep);border:1px solid var(--cloth-line);border-radius:var(--radius);transition:border-color var(--t-fast) var(--ease);margin:0}.hsearch-input::placeholder{color:var(--thread-2);opacity:1}.hsearch-box.has-query 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